How do you manage DLBCL in patients with previous anthracycline exposure?  

If a young and otherwise healthy patient with normal echocardiogram and no other cardiac risk factors needs treatment for DLBCL, but has previously received 6 cycles of doxorubicin with cumulative dose of around 300 mg/m2 -, would you still offer anthracycline based treated for curative intent DLBCL?

Answer from: Medical Oncologist at Academic Institution