Is there a risk of increased side effects with combined radiation and ibrutinib therapy?

Topics: Hematologic Malignancies • Radiation Oncology • Medical Oncology • Hematology

Would you change your radiation therapy treatment dose or volume if you needed to treat a chloroma? If a patient had a separate cancer (e.g. skin cancer, breast cancer, etc), would you recommend stopping Imbruvica or trying to avoid RT?

Answer from: Radiation Oncologist at Academic Institution

It is increasingly common to see patients with various hematologic malignancies requiring palliative RT who are on small molecular inhibitors (such as ibrutinib) or other novel agents. There is often a dearth of information in the medical literature regarding the safety of combining RT with these dr...

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Radiation Oncologist at Tri-County Oncology
Can you treat the patient with combined chemo and ...

Answer from: Radiation Oncologist at Community Practice

There was a similar question posted on this forum recently, only in regards to the safety of venetoclax (Bcl-2 inhibitor) and concurrent RT. As @Christopher R. Kelsey correctly mentioned, there is yet a paucity of robust data regarding the safety of these and other "novel" oral lymphoma agents when...

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