What is the best second line treatment for a Her2+ metastatic breast cancer treated with frontline Taxol/Herceptin?
Would you do a pertuzumab-based regimen or T-DM1?
Answer from: Medical Oncologist at Academic Institution
I would use T-DM1 (ado trastuzumab emtansine) in this situation as a second line therapy. T-DM1 has a very favorable side effect profile. Pertuzumab added a survival benefit when combined docetaxel and trastuzumab (median of 15.7 months) though this was a first-line treatment (Swain et al. NEJM 2015...