Cardiology

Neuro-critical care

Questions discussed in this category

How do you decide on the speed and target of blood pressure reduction for spontaneous intracranial hemorrhage?

Do you consider bleeding risk in elderly, frail patients with atrial fibrillation to be similar for all NOACs?

In FRAIL-AF, participants were switched from VKA to dabigatran, rivaroxaban, apixaban, and edoxaban.

When do you usually introduce conversations regarding tracheostomy placement in patients with refractory status epilepticus, or other conditions where one may anticipate delayed awakening?

1 Answer available

Can bleeding risk when switching from VKA treatment to a NOAC in frail, elderly patients be accurately compared if individual times in therapeutic range while on VKA treatment are not captured?

Individual times in the therapeutic range while on VKA treatment was not registered in FRAIL-AF.

2 Answers available

In what clinical scenarios do you utilize post-cardiac arrest targeted temperature management (TTM)?

In the span between the HACA trial and the Targeted Temperature Management in Out-of-Hospital Cardiac Arrest study (Dankiewicz et al., PMID 34133859),...

1 Answer available

Would you change an elderly, frail patient with atrial fibrillation who is already on a NOAC to VKA treatment?

In FRAIL-AF, switching VKA therapy to a NOAC was associated with higher risk of bleeding in elderly, frail patients.

4 Answers available

Do you think that home INR monitoring is a feasible option for elderly, frail patients with atrial fibrillation on VKA treatment, given variations in socioeconomic status and access to care?

2 Answers available

Papers discussed in this category

The New England journal of medicine, 2002-02-21

Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia.

N Engl J Med, 2013 Nov 17

Targeted temperature management at 33°C versus 36°C after cardiac arrest.

Cureus, 2022 Sep 11

Targeted Temperature Management After Cardiac Arrest: A Systematic Review.

Crit Care, 2020 Jan 06

High Quality Targeted Temperature Management (TTM) After Cardiac Arrest.

Circulation, 2023 Aug 27

Safety of Switching from a Vitamin K Antagonist to a Non-Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients with Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial.

JAMA, 2022 May 17

Effect of Early vs Standard Approach to Tracheostomy on Functional Outcome at 6 Months Among Patients With Severe Stroke Receiving Mechanical Ventilation: The SETPOINT2 Randomized Clinical Trial.

JAMA, 2013 May 22

Effect of early vs late tracheostomy placement on survival in patients receiving mechanical ventilation: the TracMan randomized trial.

The New England journal of medicine, 2013-06-20

Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage.

The New England journal of medicine, 2016 Jun 08

Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage.

The New England journal of medicine, 2024 May 16

Intensive Ambulance-Delivered Blood-Pressure Reduction in Hyperacute Stroke.

Lancet (London, England), 2023 May 25

The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial.

Cardiology

Neuro-critical care

Questions discussed in this category

Papers discussed in this category

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