Hematologic Malignancies

ASCO Journal Club

Journal Club Q&A done in partnership with ASCO the Journal of Clinical Oncology

Questions discussed in this category

Following the BRUIN data in mantle cell lymphoma, will you routinely treat with pirtobrutinib following a covalent BTKi?

Is the data sufficient to change your practice?

2 Answers available

Will you recommend pirtobrutinib following a prior covalent BTKi in patients with cardiac comorbidities?

Does cumulative exposure to BTKi increase potential risk of cardiac toxicity?

2 Answers available

What subsequent therapies did patients receive after progressing on pirtobrutinib in the mantle cell BRUIN trial population?

Should pirtobrutinib be viewed as a bridge to CAR-T or transplant or a destination therapy?

2 Answers available

Are there biomarkers or other factors to help predict which patients with MCL are most likely to benefit, or not, from pirtobrutinib following a prior covalent BTKi?

How do you predict which patients may be in a high risk group and less likely to benefit from a second BTKi?

2 Answers available

What are the factors that convince you to not immediately treat mantle cell lymphoma and to follow a course of "active surveillance"?

Is there a specific Ki67 percentage? P53-negativity?

3 Answers available

Papers discussed in this category

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009-03-10

Outcome of deferred initial therapy in mantle-cell lymphoma.

J. Clin. Oncol., 2009 Oct 05

Time to treatment does not influence overall survival in newly diagnosed mantle-cell lymphoma.

Ann. Oncol.,

Observation as the initial management strategy in patients with mantle cell lymphoma.

Cancer Res., 2010 Feb 02

Genomic and gene expression profiling defines indolent forms of mantle cell lymphoma.

Haematologica, 2019-04

Clinical presentation determines selection of patients for initial observation in mantle cell lymphoma.

J Clin Oncol, 2023 May 16

Pirtobrutinib in Covalent Bruton Tyrosine Kinase Inhibitor Pretreated Mantle-Cell Lymphoma.

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