Hematology

General Hepatology

Questions discussed in this category

For pediatric patients with iron overload (high ferritin and transferrin saturation), do you perform HFE screening first, or proceed to non-HFE gene sequencing upfront to evaluate for HJV mutation as well?

Especially considering that family history is not fully available.

1 Answer available

What parameters would you use to monitor and interpret iron levels in a hemochromatosis patient where ferritin is unreliable due to underlying chronic inflammation?

How would your recommendation change if the patient has H63 homozygous mutation?

2 Answers available

Would you anticoagulate an SMV thrombosis caused by malignant obstruction in the setting of metastatic colorectal cancer?

For what duration and is there a preferred anticoagulation agent?

1 Answer available

Can defibrotide be given safely for VOD in patients with refractory thrombocytopenia to platelet transfusions?

1 Answer available

In a patient with amyloidosis and abnormal liver function but child Pugh A, would you still proceed with SABR for a liver metastasis?

1 Answer available

How long do you anticoagulate for cirrhosis patients who have portal vein thrombosis extending to the mesenteric veins?

2 Answers available

To what extent does the degree of thrombocytopenia correlate with the severity of cirrhosis?

1 Answer available

Do you routinely start anticoagulation for a patient with newly diagnosed hepatocellular carcinoma presenting with a portal venous thrombosis?

3 Answers available

Papers discussed in this category

Blood, 2020 Sep 10

Anticoagulant therapy for splanchnic vein thrombosis: A systematic review and meta-analysis.

Blood Adv,

American Society of Hematology 2021 guidelines for management of venous thromboembolism: prevention and treatment in patients with cancer.

Blood, 2014 Oct 15

How I treat splanchnic vein thrombosis.

Blood, 2016-03-31

Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure.

Bone marrow transplantation, 2016-07

Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation.

Bone marrow transplantation, 2018-02

Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in pediatric patients: a new classification from the European society for blood and marrow transplantation.

British journal of haematology, 2020 Mar 04

Modified diagnostic criteria, grading classification and newly elucidated pathophysiology of hepatic SOS/VOD after haematopoietic cell transplantation.

Blood advances, 2022 Jan 11

Defibrotide: real-world management of veno-occlusive disease/sinusoidal obstructive syndrome after stem cell transplant.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2020 Jan-Dec

A Meta-Analysis Evaluating the Incidence of Bleeding Events With Intravenous Defibrotide Treatment Outside the Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome Setting.

Bone marrow transplantation, 2022 Dec 23

Real-world use of defibrotide for veno-occlusive disease/sinusoidal obstruction syndrome: the DEFIFrance Registry Study.

Journal of thrombosis and haemostasis : JTH, 2024 Oct 21

Splanchnic vein thrombosis: management for the thrombosis specialist.

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