Primary Care

Pegloticase

Questions discussed in this category

Do you still consider the use of pegloticase in someone with substantial tophaceous burden despite optimal uric acid levels?

For example, patient with sUA <4 already on maximum dose allopurinol or Uloric, but significant tophi that have only marginally reduced in si...

1 Answer available

When do you consider discontinuing Pegloticase in a patient with tophaceous gout who has had excellent response to therapy?

1 Answer available

Papers discussed in this category

Arthritis and rheumatism, 2008-09

Reduction of plasma urate levels following treatment with multiple doses of pegloticase (polyethylene glycol-conjugated uricase) in patients with treatment-failure gout: results of a phase II randomized study.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2014-12

Infusion-related reactions with pegloticase, a recombinant uricase for the treatment of chronic gout refractory to conventional therapy.

Curr Rheumatol Rep, 2022 Feb 15

Expert Opinion on Pegloticase with Concomitant Immunomodulatory Therapy in the Treatment of Uncontrolled Gout to Improve Efficacy, Safety, and Durability of Response.

Arthritis Rheumatol, 2020 Jan

Effects of Conventional Uric Acid-Lowering Therapy on Monosodium Urate Crystal Deposits.

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