Pulmonology

Myositis

Questions discussed in this category

In light of the RECITAL study, would rituximab be a reasonable choice in a patient with PL-12 antibodies, rapidly progressive pulmonary disease with organizing pneumonia on biopsy?

Given poor pulmonary outcomes in people with anti-PL12 antibodies, would you recommend more aggressive therapy? The patient was diagnosed with onset o...

1 Answer available

What is the risk of ILD recurrence in MDA5/Ro52 positive dermatomyositis following a lung transplantation?

2 Answers available

Do you screen for interstitial lung disease in patients with newly diagnosed polymyositis or dermatomyositis in the absence of respiratory symptoms?

3 Answers available

How would you manage subclinical ILD associated with MDA-5 Dermatomyositis?

Any indications for triple therapy in the patients with subclinical ILD associated with MDA-5 dermatomyositis?

1 Answer available

What workup do you do for patients who have PL-7 elevation when screening for myopathy?

2 Answers available

What is your approach to treatment for MDA5 dermatomyositis patients with rapidly progressive ILD?

Cyclophosphamide/tacrolimus and Rituximab have been used in conjunction with steroids in case series.

1 Answer available

When do you use tacrolimus in patients with myositis-related interstitial lung disease?

1 Answer available

What agent do you try next in patients with myositis-related interstitial lung disease who are refractory to mycophenolate mofetil and azathioprine?

1 Answer available

What is your next step in patients with polymyositis without interstitial lung disease who are refractory to methotrexate?

1 Answer available

Papers discussed in this category

N Engl J Med,

Tofacitinib in Amyopathic Dermatomyositis-Associated Interstitial Lung Disease.

J Heart Lung Transplant, 2021 Nov

Consensus document for the selection of lung transplant candidates: An update from the International Society for Heart and Lung Transplantation.

Interact Cardiovasc Thorac Surg, 2015 Jan 07

Recurrent polymyositis-associated lung disease after lung transplantation.

Rheumatology (Oxford, England), 2011 Dec 30

Disappearance of anti-MDA-5 autoantibodies in clinically amyopathic DM/interstitial lung disease during disease remission.

Rheumatology (Oxford, England), 2017-06-01

A longitudinal cohort study of the anti-synthetase syndrome: increased severity of interstitial lung disease in black patients and patients with anti-PL7 and anti-PL12 autoantibodies.

Autoimmun Rev, 2012 Jul 05

Hierarchical cluster and survival analyses of antisynthetase syndrome: phenotype and outcome are correlated with anti-tRNA synthetase antibody specificity.

Lancet Respir Med, 2023 Jan

Rituximab versus intravenous cyclophosphamide in patients with connective tissue disease-associated interstitial lung disease in the UK (RECITAL): a double-blind, double-dummy, randomised, controlled, phase 2b trial.

Pulmonology

Myositis

Questions discussed in this category

Papers discussed in this category

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