How do you approach urate-lowering therapy in patients with advanced chronic kidney disease?

Topics: Rheumatology • Crystal Arthritis • Gout • Allopurinol • Chronic kidney disease • Nephrology

What doses of allopurinol do you use, and how frequently do you titrate the dose?

Answer from: at Academic Institution

I lower uric acid independent of GFR. There is little evidence to support limiting uric acid-lowering therapy. This misinformation came out due to combining fears that the incidence of allopurinol reactions would increase in patients with renal insufficiency. Allergic reactions are related to expos...

Comments

at Nephrology Specialists Pc
Why the low starting dose when you have just state...

at Texas Tech University Health Sciences Center
I do check for B58.01. Probably don't need low dos...

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