How do you counsel your PALB2 mutation positive breast cancer patients with regards to risk reducing surgery?

Topics: Breast Cancer • Surgical Oncology • Breast Surgery

How does this mutation compare to BRCA mutations in terms of risk and screening implications for family members?

Answer from: at Academic Institution

I counsel patients with PALB2 mutations that their lifetime risk of breast cancer approaches that of a BRCA2 carrier. There is some element of penetrance of the gene in a familial cohort so that the lifetime risk of breast cancer ranges from about 30% to almost 60% (Antoniou et al. NEJM 2014). Despi...

Comments

at Gynecology Practice Wiesbaden
Thank you! Is there data on contralateral breast c...

Medical Oncologist at University of Iowa Holden Comprehensive Cancer Center
There is limited data to support prophylactic surg...

at Gynecology Practice Wiesbaden
Thank you!

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