How do you counsel your PALB2 mutation positive breast cancer patients with regards to risk reducing surgery?

How does this mutation compare to BRCA mutations in terms of risk and screening implications for family members?

1 Answer

Mednet MemberInvited Expert

Surgical Oncology · Virginia Commonwealth University School of Medicine

Answered on

I counsel patients with PALB2 mutations that their lifetime risk of breast cancer approaches that of a BRCA2 carrier. There is some element of penetrance of the gene in a familial cohort so that the lifetime risk of breast cancer ranges from about 30% to almost 60% (Antoniou et al. NEJM 2014). Despi...

Join for free or sign in to see the full answer