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How do you prescribe Perampanel for use in patients with refractory status epilepticus?
What is the your preferred loading (and maintenance) dose for use of Perampanel in the treatment of refractory status epilepticus?
Answer from: at Academic Institution
LD: 6-12 mg
MD: 12 mg/day
Use not recommended in severe renal impairment (CrCl <30 ml/min).
Consider dose reduction in mild to moderate hepatic impairment. Use is not recommended in severe hepatic impairment.
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Answer from: at Academic Institution
There are no set recommendations and I can only report anecdotal evidence. For refractory or super-refractory status epilepticus, a loading dose of 24mg followed by maintenance of 12mg bid is well tolerated at least as per my experience. I have had success with several super-refractory epilepsy pati...
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at University of Texas Health Science Center at Houston
Do you think it can be used in conjunction with a ...
Do you think it can be used in conjunction with a ...