How do you work up a young patient with increasing ferritin and normal TSAT without infectious, inflammatory, or liver disorders?  

Ferritin uptrending >1000, no additional lab abnormalities. HFE wildtype. Too young for age-appropriate cancer screening. Asymptomatic except fatigue. 

Answer from: Medical Oncologist at Academic Institution
Medical Oncologist at Chicago Health Medical Group
Consider lymphohistiocytosis.
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