In a young female with severe osteoporosis due to congenital estrogen deficiency, can estrogen be prescribed if genetic testing for congenital disorders reveals a heterozygous Factor V Leiden mutation?

Topics: Pediatric Oncology • Thrombosis • Hematology • Pediatric Hematology • Benign Hematology • Hemostasis/Thrombosis • Anticoagulation • Endocrinology

No prior thrombosis; no family history of thrombosis. As per endocrine, the only useful therapy for the osteoporosis is estrogen.

Answer from: at Academic Institution

First of all, I don't think testing for inherited thrombophilia is warranted in a patient with no personal or family history of thrombosis. Given the multigenic nature of thrombophilia and our limited ability to test for it, it's difficult if not impossible to determine an individual's risk of throm...

Comments

Medical Oncologist at NYU Langone Medical Center
I completely agree with your comments. The genetic...

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