Immune Checkpoint Inhibitor Myocarditis Treatment Strategies and Future Directions.

JACC CardioOncol 2022 Dec 20

Related Questions

When would you consider tapering glucocorticoids in a patient with ICI-associated myocarditis?

New answer by at University of Texas Southwestern Medical School (May 31, 2023)

Patients with ICI myocarditis are treated with 1g solumedrol for 3-5 days and then transitioned to oral prednisone at 1mg/kg per day. In general, a slow prednisone taper is re...

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For patients on immune checkpoint inhibitors presenting with chest pain, dyspnea, fatigue, and troponin elevation, would you recommend early initiation of high dose steroids for empiric treatment of ICI myocarditis while pursuing workup with coronary angiogram, echocardiogram, and/or cardiac MRI, or wait until alternative etiologies have been ruled out?

New comment by at FibroFighters Foundation ( June 29, 2023)

Do you use tocilizumab? Or only if steroids fail? I ask because tocilizumab has anti-cancer properties and can promote IL-12 - which enhances immune-mediated cancer effect, w...

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