Int J Radiat Oncol Biol Phys 2021 Mar 04
Involved-Field Irradiation in Definitive Chemoradiotherapy for Locoregional Esophageal Squamous Cell Carcinoma: Results from the ESO-Shanghai 1 Trial.   
ABSTRACT
OBJECTIVE
To evaluate the feasibility and efficacy of involved-field irradiation in definitive chemoradiotherapy for loco-regional esophageal squamous cell carcinoma.
PATIENTS AND METHODS
Patterns in recurrence and elective nodal failure were analyzed in patients from the previously published XXXXXX trial, who received definitive chemoradiotherapy with involved-field irradiation to 61.2 Gy in 34 fractions using intensity-modulated radiation therapy planning. Nodal regions were delineated using the lymph node map from the sixth edition of the American Joint Committee on Cancer (AJCC) staging system. Elective nodal failure was defined as recurrence in the regional nodal area outside the planning target volume. Extensive elective nodal failure, defined as an extensive nodal area regardless of tumor location, was calculated for additional analysis. The incidental (i.e. mean) irradiation dose of each node and each region was evaluated.
RESULTS
With a median follow-up of 48.7 months among survivors, the 3-year actuarial rate for overall survival was 53.6%, and the median overall survival was 44.8 months (95% CI: 34.6-55.0). Of the 436 patients included in this study, 258 patients (59.2%) experienced treatment failure. Elective nodal failure was experienced by 37 patients (8.5%), only 7 (1.6%) of whom encountered nodal-only failure. The 3-year actuarial rates of elective nodal control and elective nodal-only control were 89.7% and 97.9%, respectively. The median incidental dose of these nodes was 33.2 Gy [interquartile range (IQR): 1.3-50.7 Gy)]. The median distance of each node to the planning target volume was 1.4 cm (IQR: 0.6-4.9 cm). Extensive elective nodal failure was experienced by 51 patients (11.6%), while 20 (4.6%) patients had nodal-only failure. The 3-year extensive elective nodal control and extensive elective nodal control-only rates were 86.0% and 94.3%, respectively. The median incidental dose of these nodes was 23.2 Gy (IQR: 1.1-53.5 Gy). The median distance of each node to the planning target volume was 2.0 cm (IQR: 0.6-5.5 cm).
CONCLUSION
Involved-field irradiation can achieve a low rate of isolated nodal failure and a satisfactory survival outcome. The use of elective nodal irradiation may be unnecessary in definitive chemoradiotherapy for the treatment of locoregional esophageal squamous cell carcinoma.

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