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JCO precision oncology 2025 Oct 30
Multi-Institution Analysis of Tarlatamab for the Treatment of -Mutant Transformed Small Cell Lung Cancer.
Related Questions
In cases where EGFR NSCLC has transformed into small-cell lung cancer after treatment with osimertinib, and with no CNS involvement, is it advisable to continue osimertinib alongside chemotherapy?
Furthermore, should adding immunotherapy be considered?
New answer
by Medical Oncologist at Cancer Care Specialists/Renown Oncology/UNR (November 2, 2025)
Also, tarlatamab doesn’t work well in these despite high DLL3 expression, per this small series Cooper et al., PMID 41166675.
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