Clinical cancer research : an official journal of the American Association for Cancer Research 2018-02-15
Mutations in Homologous Recombination Genes and Outcomes in Ovarian Carcinoma Patients in GOG 218: An NRG Oncology/Gynecologic Oncology Group Study.   
We hypothesized that mutations in homologous recombination repair (HRR) genes beyond and improve outcomes for ovarian carcinoma patients treated with platinum therapy and would impact the relative benefit of adding prolonged bevacizumab. We sequenced DNA from blood and/or neoplasm from 1,195 women enrolled in GOG-0218, a randomized phase III trial in advanced ovarian carcinoma of bevacizumab added to carboplatin and paclitaxel. Defects in HRR were defined as damaging mutations in 16 genes. Proportional hazards models were used to estimate relative hazards for progression-free survival (PFS) and overall survival (OS). Of 1,195 women with ovarian carcinoma, HRR mutations were identified in 307 (25.7%). Adjusted hazards for progression and death compared with those without mutations were lower for women with non- HRR mutations [HR = 0.73; 95% confidence interval (CI), 0.57-0.94; = 0.01 for PFS; HR = 0.67; 95% CI, 0.50-0.90; = 0.007 for OS] and mutations (HR = 0.80; 95% CI, 0.66-0.97; = 0.02 for PFS; HR = 0.74; 95% CI, 0.59-0.94; = 0.01 for OS) and were lowest for mutations (HR = 0.52; 95% CI, 0.40-0.67; < 0.0001 for PFS; HR = 0.36; 95% CI, 0.25-0.53; < 0.0001 for OS). A test of interaction showed no difference in the effect of bevacizumab on PFS between cases with and without mutations. HRR mutations, including non- genes, significantly prolong PFS and OS in ovarian carcinoma and should be stratified for in clinical trials. The benefit of adding bevacizumab was not significantly modified by mutation status. .

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What specific platforms for determining somatic BRCA and HRD status do you use for a patient who does not carry a germline BRCA mutation?