World journal of oncology 2023 Feb 26
Postoperative Chemotherapy After Surgical Resection of Metachronous Metastases of Colorectal Cancer: A Systematic Review.
ABSTRACT
Currently, 6 months of perioperative or adjuvant chemotherapy (ACT) is a standard treatment option after radical surgical removal of metachronous metastases in patients with metastatic colorectal cancer (CRC). Data show that ACT improves relapse-free survival in such patients, although no difference in overall survival rate was observed. We perform a systematic review to evaluate the efficacy of adjuvant chemotherapy after radical resection of metachronous metastases in CRC.
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Without any high-risk features and with low MSI.
New comment by Medical Oncologist at Los Angeles VA Medical Center ( July 14, 2025)
I hear you, Dr. @Noelle K. LoConte, that's the context I hear synchronous/metachronous as well. I usually just say new primary. I interpret this to mean if a patient has two o...