Acta Inform Med 2014-04-01
Spinal Dissemination of Intracranial Glioblastoma in Bevacizumab Era: a Potential Bevacizumab-induced Mechanism.
ABSTRACT
Spinal metastasis, a devastating neurologic complication of intracranial glioblastomas is not as uncommon as initially thought. It varies from 25% in supratentorial glioblastomas to 60% in infratentorial glioblastomas. The underlying pathogenesis spinal spread of high-grade gliomas is still unclear. To date, no causal responsibility of Bevacizumab (BEV) was noted. Here, we report for the first time, a case of thoracic intramedullary metastases from a cerebral glioblastoma pre-treated with BEV. A critical and exhaustive review is provided.
Related Questions
In particular, for patients without clinical symptoms, would you image the spine based on any histologic, molecular, or other risk factors?
New answer by Radiation Oncologist at Cleveland Clinic (April 3, 2017)
I do not routinely image the spine following workup of an intracranial glioma. It is not because they are not common because in fact, it can be found in 25% of patients with ...