Int J Radiat Oncol Biol Phys 2012 Jul 15
Treatment outcomes in non-metastatic prostate cancer patients with ultra-high prostate-specific antigen.   

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In other words, is there a PSA value above which metastases are imminent?

Is there an upper limit to offer definitive RT? Is it possible to have a PSA of 100-500 and still have only local disease?