What are the best practices for centers interested in providing anti-amyloid therapies for early Alzheimer's to ensure treatment delivery success?
After initiating a patient on anti-amyloid antibody therapy, what are the biggest logistical barriers to ensuring long-term compliance with treatment?
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I would use the same criteria for AAA treatment as those required for entering AAA clinical trials. Overall, our center has not had difficulty with ensuring that patients have timely MRIs before treatments. I enlist caregivers and patients to remind me when they are scheduled for their next infusion...
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Proper and expedited selection of subjects is fundamental. It is crucial to have processes in place to assure safety monitoring and follow-up in case of adverse events.
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Adequate training of radiologists is my biggest barrier. I've had even radiologists who were part of the CLARITY-AD study miss superficial siderosis, which I believe would have been criteria to disenroll them.
I've had radiologists who said they were part of AAA trials miss ARIA.
I also just recently ...
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