Do the higher rates of grade 1–2 pulmonary fibrosis with hypofractionated PMRT in CHN HYPOPMRT change how you counsel patients about long-term lung toxicity when choosing between fractionation schedules?
This question is part of our ASTRO 2026 collaboration, inspired by the Plenary Session Presentation "Hypofractionated vs. Conventional Fractionated Postmastectomy Radiotherapy in High-Risk Breast Cancer: 10-Year Outcomes from a Phase 3 Randomized Trial" by Dr. Guang-Yi Sun, MD
1 Answer
Mednet MemberInvited Expert
Radiation Oncology · Harvard Medical School
Answered on
The higher rate of grade 1-2 pulmonary fibrosis with hypofractionated postmastectomy radiotherapy in CHN HYPOPMRT does not change my recommendation. The excess toxicity is confined to grade 1-2 disease—largely radiographic or mildly symptomatic fibrosis. Importantly, the abstract reports grade 1-2 f...
Join for free or sign in to see the full answer