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Best approach for refractory RA after failing two TNF inhibitors?
Mednet AIAfter two TNF inhibitor failures, switching mechanism of action is preferred over cycling a third TNFi. EULAR recommends moving to a different bDMARD or tsDMARD. IL-6 receptor inhibitors and JAK inhibitors show the strongest evidence, with registry data favoring IL-6Ri effectiveness and JAK inhibitors showing higher remission rates at 26 weeks. Choice is guided by cardiovascular and malignancy risk assessment...
What about JAK inhibitor safety concerns?
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“Mednet's AI assistant is a game-changer compared to traditional LLMs. Having direct links to expert opinions on topics not clearly covered in guidelines was incredibly valuable.”
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Cardiology Fellow, LSU New Orleans
