Do you attempt treatment breaks from bispecific antibody therapy in patients with relapsed myeloma who achieve a sustained MRD-negative complete response?

I have not seen any reported data on this, so no.

Here is the only information that I have adjacent to this question:

1. I generally don't repeat bone marrow biopsies on patients receiving bispecific antibody therapy, so I have little experience with sustained MRD-negative CR's. I certainly have done ...

I don't attempt to stop therapy in people who achieve deep responses and are tolerating the drug, but this is mostly because there is currently a paucity of prospective trials, so the specific time at which stopping therapy is optimal has not been established. I do have a low threshold to space out ...

If the patient has had at least 12 months of therapy and has achieved MRD-negative complete response, I would give consideration to treatment breaks, especially if the patient has had significant issues with hypogammaglobulinemia, infections, or the desire to be off therapy. The patient does not nee...