Do you de-escalate back to medium-dose ICS after starting dupilumab in a patient whose uncontrolled severe asthma had not responded adequately to high-dose ICS?

Yes, I will often de-escalate if patients are well controlled after adding a biologic. In fact, I have had times when patients decrease the frequency of their dose or even stop their controller inhalers (on their own) after a good response to biologic therapy. In these cases, it can sometimes be a c...