Do you find the pCR improvement with neoadjuvant ultra-hypofractionated RT in NeoORB compelling enough to start considering sequencing radiation before surgery in selected breast cancer patients?

Adjuvant radiation remains the standard of care in breast cancer; however, the concept of pre-operative or neoadjuvant radiation (NART) has held durable appeal for both early-stage and locally advanced breast cancer due to several potential advantages. First, it allows for treatment to intact anatom...

The NeoORB findings are intriguing and reassuring in that preoperative ultra-hypofractionated radiotherapy appears feasible and is associated with substantial increases in both breast and nodal pathologic complete response. However, I would view these results as requiring further investigation befor...