Does your threshold for the duration of induction chemotherapy differ if opting for neoadjuvant SBRT vs chemoradiation in resectable pancreatic cancer?
This question is part of our ASTRO 2026 collaboration, inspired by the LBA Session Presentation "A Randomized Phase II Clinical Trial of Stereotactic Body Radiation Therapy or Conventionally Fractionated Concurrent Chemotherapy and Radiation Therapy Preoperatively for Pancreatic Adenocarcinoma" by Dr. William Hall, MD
2 Answers
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Radiation Oncology · Medical College of Wisconsin
Answered on
No, most patients treated in the LaBahn/MCW pancreatic cancer program undergo treatment on a clinical trial. Outside of a trial, total neoadjuvant therapy typically starts with systemic therapy given for at least 2-4 months. While most patients are treated in the setting of a clinical trial, when pa...
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Mednet Member
Radiation Oncology · University of Michigan
Answered on
The role of preoperative therapy for resectable pancreatic cancer in general is still an open question in my mind, given some questioning of its benefit, such as the NORPACT trial [Labori et al., PMID 38237621]. In addition, in the PREOPANC trial, the benefit of preoperative therapy (which included ...
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