Following the ECHO trial, are you routinely incorporating acalabrutinib plus bendamustine-rituximab into your frontline treatment approach for patients with MCL?

I routinely discuss the combination of BR+ acalabrutinib for my patients with TP53 WT disease, but am upfront that it is not a "once size fits all" approach. I discuss that we are clearly seeing a progression free benefit of adding acala to BR, but we don't actually know at this time if giving them ...

Yes, but usually for higher risk patients (MIPI and/or Ki67, mTP53), since the increased infectious toxicity in ECHO — while related COVID-era study conduct — has to be considered, and randomized+ observational data suggest a similar long term overall with sequential BR — BTK on relapse overall.