How do you approach palliative RT dose selection to skeletal lesions in patients with Myeloma who are actively receiving or likely to need systemic therapy?

Multiple myeloma patients with painful bone disease often present a unique constellation of clinical characteristics, such as extensive skeletal involvement, longer life expectancies, and many prior or anticipated systemic treatments. Some key features influencing my choice of radiation dose and sch...

In patients with multiple myeloma who are actively receiving or likely to need systemic therapy, I generally favor the lowest effective radiation dose that achieves the clinical objective while minimizing marrow exposure and disruption of systemic treatment. This is particularly important in myeloma...