How do you decide how many sites to treat with SBRT in a patient with metastatic Ewing sarcoma?
AEWS1221 supported CMDT for all baseline metastatic sites but was not stratified by baseline metastatic burden. Do you factor that in?
This question is part of our ASTRO 2026 collaboration, inspired by the Clinical Trials Session Presentation "Stereotactic Body Radiation Therapy (SBRT) and Comprehensive Metastasis-Directed Therapy for Ewing Sarcoma Patients Enrolled on AEWS1221: A Report from the Children's Oncology Group (COG)" by Dr. Nadia Laack, MD, MS
1 Answer
Mednet Member
Radiation Oncology · Harvard Medical School
Answered on
In patients with 5 or fewer metastatic sites, it is a very reasonable approach to be comprehensive and treat the primary (if required) while saving the metastatic sites until the end of treatment. When more than 5 sites require treatment, I prioritize metastatic sites that have not had a complete re...
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