For patients with severe eosinophilic asthma who continue to have exacerbations on benralizumab due to a viral/bacterial etiology, is azithromycin a reasonable add on therapy?

I would reassess the effectiveness of the biologic. Are they developing breakthrough eosinophilia during these exacerbations, thereby suggesting that the drug may not be as effective and consider switching the biologic? Consider repeating biomarkers like FeNO, and eosinophils to assess if there is a...

There is data suggesting benefit in mucopurulent/chronic bronchitis/infectious phenotype; however, in clinical practice, I focus first on managing concomitant comorbidities, including weight loss, GERD & OSA.