How do you manage high-threshold food allergies beyond strict avoidance?
The child only reacts to cashew at the highest dose in each challenge and currently has been doing avoidance so should they be maintained on the highest dose before reacting or start OIT?
2 Answers
Mednet MemberInvited Expert
Allergy & Immunology · University of Chicago
Answered on
Thanks for the question Dr. @Dr. First Last.
The field is moving beyond a strict avoidance-only option, and this is an evolving area in managing patients who have food allergies but react at higher thresholds.
For patients with evidence of a higher reaction threshold, I still start from a foundation o...
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Mednet MemberInvited Expert
Allergy & Immunology · Case Western Reserve University, School of Medicine
Answered on
I would recommend starting with OIT. You do not necessarily have to begin at the very lowest possible dose, but it is important to start at least 10–20 fold below the patient’s established threshold. This allows you to build some degree of desensitization before approaching—and eventually exceeding—...
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