How long after starting ADT + Abiraterone can capivasertib still be safely incorporated in patients where PTEN testing is delayed?

In the CAPItello-281 clinical trial (NCT04493853; Fizazi et al., PMID 41120017), patients were allowed to enroll with prior ADT/abiraterone therapy as long as it did not exceed 3 months. It is plausible that starting capivasertib after a longer delay might still provide additional efficacy over ADT/...

If PTEN results return within the first several weeks to approximately 3 months, I would be comfortable adding capivasertib in an otherwise appropriate patient. I would not intentionally delay therapy simply to test the effectiveness of abiraterone first. Beyond the trial's approximately 93-day wind...