How might treatments beyond immunomodulating therapies be important for MS?

Current disease-modifying therapies are very effective at controlling inflammatory activity, but they incompletely address other aspects of the underlying pathophysiology of multiple sclerosis (MS), including progression, neurodegeneration, and CNS repair. Future approaches may therefore complement ...

I think this is one of the most interesting directions for future MS treatment. We have become remarkably good at suppressing the peripheral inflammatory component of MS, particularly with high-efficacy therapies, but we are much less successful at preventing the more chronic processes that ultimate...

Current approved therapies for MS are immunomodulating or immunosuppressive. All of them show efficacy regarding disease activity and, to some extent, also on progression of disability, especially during early intervention. However, the ability to influence chronic compartmentalized inflammation and...