In a young female with lupus cerebritis with seizures would you start induction therapy with Rituximab over cyclophosphamide?

I am not aware of a direct comparison of the efficacy of cyclophosphamide versus rituximab for treating lupus cerebritis with seizures. In cases of life-threatening progressive disease, giving both agents has been reported. Choosing between the two should involve in-depth patient education and invol...

The mainstay of treatment for lupus cerebritis or severe inflammatory neuropsychiatric SLE (such as seizures, cerebral vasculitis, psychosis, or encephalopathy attributed to lupus, myelitis) harbors on pulse-dose glucocorticoids followed by a prednisone taper, as well as cyclophosphamide. Cyclophosp...

No, I would choose National Institutes of Health (NIH) Cytoxan, as I've had to switch patients over from rituximab to Cytoxan for this indication. In my experience, I've had more success with Cytoxan as monotherapy, but I often also have to add more therapies, such as intravenous immunoglobulin (IVI...