What is your approach for monitoring disability progression in patients with MS?

My standard approach to MS patient visits includes asking about past/chronic symptoms and whether they are stable or worsening. I also ask a review of (neuro) systems with particular focus on gait change, bladder dysfunction, and cognitive concerns, as these are strongly associated with disease prog...

We utilize PROs such as Neuro-Qol as well as self-administered T25FW, 9HPT, and a processing speed test performed at each in-person visit when possible. I find it helpful to periodically (such as on an annual basis) review trends over time with the patient. Additionally, for screening, I ask patient...

In my clinical practice, all patients with MS undergo structured assessment for disability progression at each visit. This includes the Timed 25-Foot Walk (T25FW), a detailed neurologic examination, and an estimation of the EDSS. I also use a standardized MS clinic template that systematically asses...

Current strategies for monitoring disability progression in multiple sclerosis acknowledge that a significant portion of long-term disability accrual results from progression independent of relapse activity (PIRA), which may manifest early during the relapsing phase. Therefore, monitoring protocols ...