What would be the next recommended treatment option for a patient with VEXAS syndrome and a significant history of coronary artery disease who developed cytopenias and was unable to tolerate tocilizumab?

Seems like a very tough patient. If the patient has myelodysplastic syndrome or another hematologic malignancy (given he has cytopenias, there is a good likelihood), one option is to send him to hematology for treatment with azacitidine. In the French VEXAS study group, there was a 41% inflammatory ...