When is SBRT appropriate as neoadjuvant treatment for resectable pancreatic cancer?
What is your preferred dosing/fractionation, and do you routinely include elective nodal coverage?
This question is part of our ASTRO 2026 collaboration, inspired by the LBA Session Presentation "A Randomized Phase II Clinical Trial of Stereotactic Body Radiation Therapy or Conventionally Fractionated Concurrent Chemotherapy and Radiation Therapy Preoperatively for Pancreatic Adenocarcinoma" by Dr. William Hall, MD
2 Answers
Mednet Member
Radiation Oncology · University of Michigan
Answered on
The results of the SOFT trial show that SBRT is an appropriate preoperative radiation regimen for patients receiving preoperative therapy for pancreatic cancer. It has been used in the preoperative setting in retrospective and prospective studies for borderline resectable disease, and the SOFT trial...
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Mednet MemberInvited Expert
Radiation Oncology · Medical College of Wisconsin
Answered on
Radiation therapy for operable pancreatic cancer minimizes local recurrence and maximizes the rate of tumor response. To cure patients with pancreatic cancer, the tumor cannot recur locally. New ways of giving radiation can be efficient and well tolerated. The optimal radiation sequencing (with syst...
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