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After remission from a first episode of psychosis how long do you continue antipsychotic treatment before attempting taper or discontinuation?

How do you define “remission” before considering a taper? What minimum duration of stability do you typically require? What patient-specific factors influence your decision-making? How do you counsel patients about relapse risk?
2 Answers
Mednet MemberInvited Expert
Psychiatry · UPMC
Answered on

I don't think this is a one-size-fits-all question. This will depend on a number of factors. Probably most important is the client's attitude toward medication and their experience with it. Those who have done well with medication and have had no problems with side effects may be more comfortable continuing for an extended period, while those who have had difficulties may be more anxious to try for an earlier taper. It's important to make young people aware of the risks associated with discontin...

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Mednet Member
Psychiatry · Kaiser Permanente
Answered on

In general, at least 6 months, ensuring full stability, and if the stressors that led to psychosis are resolved (family conflicts, work stressors, relationship stressors, etc.), or if they are fully sober from an agent that may have caused psychosis (cannabis, meth, etc.), so at least 6 months of sobriety, and with confidence they can maintain sobriety, etc. Refer to addiction medicine if needed; continue therapy to help with learning coping/CBT skills - talk about how life stressors or substanc...

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