After what time frame off GLP-1 RA therapy should you restart at the lowest starting dose?
Patients may have to stop glp1 a therapy due to supply issues or for other reasons. If they are off for 4 weeks, is it ok to restart at the same dose they were taking before they stopped?
Community PollStarted
After how many weeks off GLP-1 RA therapy do you restart at the lowest starting dose?
47 physicians have voted
Join Mednetto vote and see how they answered.
2 Answers
Mednet MemberInvited Expert
Endocrinology · Tufts Medical Center Physicians Organization
Answered on
When a patient has stopped an incretin agonist for more than 2 weeks, I suggest at least restarting at a reduced dose. After 3-4 weeks, I would suggest restarting at the lowest or next to lowest dose. Restarting at a higher dose with anti-nausea medication such as ondansetron may be an option for so...
Join for free or sign in to see the full answer
Mednet MemberInvited Expert
Endocrinology · John H Stroger Jr Hospital of Cook County
Answered on
I would usually restart the medication at the lowest dose if it has been 3-4 weeks, as with the half life of the current GLP-1RA, their levels should be almost gone. Also there is the issue of prioritizing long term adherence versus short term control. If patients have GI side effects with a restart...
Join for free or sign in to see the full answer