Are CGRP antagonists effective at aborting intractable headaches in hospitalized patients when traditional “migraine cocktails” have failed?

The time has come for us to limit ourselves in our treatment of migraine patients to migraine-specific medications. These are the triptans and gepants for abortive treatment and the CGRP antibodies and gepants for preventive treatment. The "migraine cocktails" that we employ in emergency room and hospital admission settings consist of concoctions of non-specific medications such as opioid and non-opioid pain medications, anti-nausea medications, antihistamines, anticonvulsants, etc.

I personally...

I wish we had a definitive answer to this question, but honestly, our evidence for managing hospitalized patients is still quite limited, especially if the initial treatment approach doesn't yield results. Complicating matters further is the variability in what constitutes a "migraine cocktail". Instead of relying on this term, it's more helpful to specify the individual components of the treatment regimen.

In such situations, we often draw on anecdotal evidence and theorize based on the limited ...