Are docetaxel and paclitaxel interchangeable for stage II-III HER2+ breast cancer patients receiving neoadjuvant chemotherapy with AC-THP?

I believe docetaxel and paclitaxel are interchangeable in AC-THP for neoadjuvant chemotherapy for HER2 positive early-stage breast cancer. Decent phase II data from MSKCC confirm that the paclitaxel combination is well tolerated with PFS similar to CLEOPATRA.

(Dang et al., PMID 25547504).

The larger question is why use AC-THP at all anymore? The TRAIN-2 data recently presented at ASCO 2020 suggest that TCHP is equivalent to AC-THP with fewer short and long-term side effects.

(https://ascopubs.org/d...