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Are there adverse consequences of suppressing serum urate levels too much?

Due to possible increased risk of neurodegenerative diseases, is there a "lower limit" of serum urate to which you titrate urate lowering therapy?
2 Answers
Mednet Member
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Rheumatology · Ohio State Dodd Rehabilitation Hospital
Answered on

It's an interesting question.

I personally do not have a lower limit that I have in mind per se, and frankly rarely see anything less than 3 in any of my patients.

But I would consider 2-3 being a range which could be deemed low and potentially an issue long term in brain health and because of its n...

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Mednet Member
Mednet Member
Rheumatology · Rheumatology Associates of Long Island
Answered on

I’m not sure there is an adequate answer to this question in 2026. All of the current published data referring to potential Neuro-protective role of uric acid levels and potentially Neuro-detrimental impact of chronically low uric acid levels are filled with significant potential bias that can’t eas...

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