Are there any circumstances in which you would recommend adjuvant chemoradiation for resected olfactory neuroblastoma?
Answer from: Radiation Oncologist at Academic Institution
Agree with Dr. @William M. Mendenhall. Our experience treating 29 patients with Kadish B and C neuro esthesioneuroblastoma with local RT if positive margins, and no neck RT when the neck was N0, resulted in 27% neck failure including in the contralateral neck. 5-year LRF rate was 29% in patients who...
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Answer from: Radiation Oncologist at Academic Institution
Nearly all. I can’t recall one I haven’t treated. And always include ENI.
Answer from: Radiation Oncologist at Academic Institution
I'd typically offer radiation to patients with large intracranial extension, Kadesh C disease. It's rare.
Answer from: Radiation Oncologist at Academic Institution
Agree with post op RT and neck ENI recs per above. Unlike the more undifferentiated versions like SNUC or Small cell, there is no routine role for chemo for a pure Esthesio NB. @Adam S. Garden and @David I. Rosenthal from MDACC published on this, see PMID 15517582.