We have a current stage IV NUT carcinoma patient. With permission, I am paraphrasing my discussions with Drs. Christopher French and Dr. Geoffrey Shapiro from Dana Farber Cancer Institute.  There is no "standard" first-line chemotherapy regimen. However, in fit patients, the current recommenda...

Any directed debulking therapy - surgical or RT - always more certain than systemic therapy. I would not entertain IO alone however, chemo-IO is not unreasonable based on case reports. Mechanistically, I struggle to believe IO to be a key component of the regimen, given these tend to be genomically ...