Topics:
Thoracic Malignancies • Medical Oncology • Immune-related adverse events • Rheumatology • Neurology
Are there any risk factors for IO induced rhabdomyolysis and how do you approach and manage it?
Answer from: at Academic Institution
IO can affect the muscle in many ways. There is a myasthenia gravis and myositis overlap. I am not sure we know whether it is rhabdomyolysis versus a CK leak vs steroid myopathy vs muscle necrosis due to something else. Did the patient have EMG or muscle biopsy? There is a lot we do not underst...
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Answer from: at Community Practice
EMG and muscle biopsy will help the diagnosis. Mild CPK elevation can be monitored in the absence of high aldolase, not sure about how to control CPK leak.