Are there any risk factors for IO induced rhabdomyolysis and how do you approach and manage it?

IO can affect the muscle in many ways. There is a myasthenia gravis and myositis overlap. I am not sure we know whether it is rhabdomyolysis versus a CK leak vs steroid myopathy vs muscle necrosis due to something else. Did the patient have EMG or muscle biopsy?

There is a lot we do not understand about IO and the autoimmune effects and we are still learning.

For the most part, I think it is important to ensure an elevated CK, to trend it. A CK leak < 1000 will not affect the kidney. Also, to ensure that the patient does not have silent myocarditis and needs a cardiac MRI.

Then the next question is can you control the CK leak -- what other drugs is the patient on such as statin, etc.

Then if the CK is mildly elevated, can you just safely con...

EMG and muscle biopsy will help the diagnosis. Mild CPK elevation can be monitored in the absence of high aldolase, not sure about how to control CPK leak.