Topics:
Breast Cancer • Medical Oncology • NCI-CCC Tumor Board Question • Yale • NCI-CCC Breast Tumor Board Question • Breast Cancer, Metastatic • Breast Cancer, Non-metastatic
Are there any scenarios you would use CDK 4/6i to treat HR-positive HER2-positive breast cancer in combination with anti-HER2 agents?
Answer from: Medical Oncologist at Academic Institution
There is a strong preclinical data demonstrating that CDK4/6 inhibition reduces the growth of HER2-positive breast cancer cell lines. However, we are still awaiting the results of phase 3 trials testing the addition of CDK4/6 inhibitors to systemic therapy for hormone receptor (HR) positive, HER2 po...
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