Are there best practices for managing or mitigating toxicity from sotorasib such as hyperbilirubinemia or edema?

Personally, I think it is important to monitor closely so that any adverse events could be detected early and acted upon quickly. Based on the package insert of sotorasib (lumakras_pi_hcp_english.pdf), liver function tests should be monitored every 3 weeks for the first 3 months of treatment then on...

While hyperbilirubinemia and edema are generally uncommon, hepatotoxicity is more often manifested as liver enzyme elevation. Patient education on signs/symptoms (e.g. nausea, vomiting, anorexia) and close monitoring are key steps to mitigate toxicity and enable dose interruption early, with subsequ...

I haven't had either of these toxicities on single agent sotorasib. The main toxicity I see in my clinic is diarrhea and abdominal pain, which can be difficult to treat. We have found that early initiation of anti-diarrheals such as imodium and lomotil is important. For many patients, it seems that ...