Are there certain patient characteristics that drive you to recommend intralesional 5-FU or MTX for a large SCC on the back?  

Intralesional 5-FU or MTX can be an option for a large SCC on the back if the patient is not a good surgical candidate due to advanced elderly age, significant co-morbidities, or for those who decline surgery. These treatments can also be used neoadjuvantly to shrink large tumors and potentially red...